Institute of Biomechanics

In vitro angioplasty of atherosclerotic human femoral arteries: analysis of the geometrical changes in the individual tissues using MRI and image processing. Annals of Biomedical Engineering, in press.

Modelling the layer-specific 3D residual stresses in arteries, with an application to the human aorta. Journal of the Royal Society Interface, in press.

Constitutive modelling of arteries. Proceedings of the Royal Society A, in press.

A calcium-driven mechanochemical model for prediction of force generation in smooth muscle. Biomechanics and Modeling in Mechanobiology, in press.

DT-MRI based computation of collagen fiber deformation in human articular cartilage: a feasibility study. Annals of Biomedical Engineering, in press.

Biaxial mechanical properties of intact and layer-dissected human carotid arteries at physiological and supra-physiological loadings. American Journal of Physiology: Heart and Circulatory Physiology, in press.

Call for standards in technical documentation of intracoronary stents. Herz,35:27-33, 2010.

A novel simulation strategy for stent insertion and deployment in curved coronary bifurcations: comparison of three drug-eluting stents. Annals of Biomedical Engineering, 38:88-99, 2010.

On modelling and analysis of healthy and pathological human mitral valves: two case studies. Journal of the Mechanical Behavior of Biomedical Materials, 3:167-177, 2010.

Assessment of the in vivo biomechanical properties of the human cervix in pregnancy using the aspiration test. A feasibility study. European Journal of Obstetrics and Gynecology and Reproductive Biology, 144S:S77-S81, 2009.

Influence of medial collagen organization and axial in situ stretch on saccular cerebral aneurysm growth. ASME Journal of Biomechanical Engineering, 131:101010 (7 pages), 2009.

On planar biaxial tests for anisotropic nonlinearly elastic solids. A continuum mechanical framework. Mathematics and Mechanics of Solids, 14:474–489, 2009.

Constitutive modelling of passive myocardium. A structurally-based framework for material characterization. Philosophical Transactions of the Royal Society A, 367:3445–3475, 2009.

Interaction of balloon catheter-stent systems with atherosclerotic lesions: a computational study. In: N. Chakfé and B. Durand (eds.), "ESVB 2009 – New Technologies in Vascular Biomaterials. Connecting Biomaterials to Arterial Structures", Chapter 7, Europrot, Strasbourg, France (2009), 89-111.

Arterial tissue in health and disease: experimental data, collagen-based modeling and simulation, including aortic dissection. In: G.A. Holzapfel and R.W. Ogden (eds.), "Biomechanical Modelling at the Molecular, Cellular and Tissue Levels", CISM Courses and Lectures No. 508, Springer: Wien, New York, (2009), 259-343.

Experimental studies and numerical analysis of the inflation and interaction of vascular balloon catheter-stent systems. Annals of Biomedical Engineering, 37:315-330, 2009.

A methodology to analyze changes in lipid core and calcification onto fibrous cap vulnerability: The human atherosclerotic carotid bifurcation as an illustratory example. ASME Journal of Biomechanical Engineering, 131:121002, 2009 (9 pages).

A theoretical model for fibroblast-controlled growth of saccular cerebral aneurysms. Journal of Theoretical Biology, 257:73-83, 2009.

Elastic properties of anisotropic vascular membranes examined by inverse analysis. Computer Methods in Applied Mechanics and Engineering, 198:3622-3632, 2009.

A phenomenological approach toward patient-specific computational modeling of articular cartilage including collagen fiber tracking. ASME Journal of Biomechanical Engineering, 131:091006 (12 pages), 2009.

A computational framework for patient-specific analysis of articular cartilage incorporating structural information from DT-MRI. GAMM-Mitteilungen, 32:157-177, 2009.

Modelling the growth and stabilisation of cerebral aneurysms. Mathematical Medicine and Biology, 26:133-164, 2009.

Coupling the hemodynamic environment to the growth of cerebral aneurysms: computational framework and numerical examples. ASME Journal of Biomechanical Engineering, 131:101003, 2009 (14 pages).

Modelling the mechanical response of elastin for arterial tissue. Journal of Biomechanics, 42:1320-1325, 2009.

A methodology to study the morphologic changes in lesions during in vitro angioplasty using MRI and image processing. Medical Image Analysis, 12:163-173, 2008.

Collagen in Arterial Walls: Biomechanical Aspects. In: P. Fratzl (ed.), "Collagen. Structure and Mechanics", Chapter 11, Springer-Verlag, Heidelberg, (2008), 285-324.

Smooth contact strategies with emphasis on the modeling of balloon angioplasty with stenting. International Journal for Numerical Methods in Engineering, 75:826-855, 2008.

Modeling of saccular aneurysm growth in a human middle cerebral artery. ASME Journal of Biomechanical Engineering, 130:051012, 2008 (10 pages).

Estimation of the distributions of anisotropic, elastic properties and wall stresses of saccular cerebral aneurysms by inverse analysis. Proceedings of the Royal Society A, 464:807-825, 2008.

A new constitutive model for multi-layered collagenous tissues. Journal of Biomechanics, 41:2766-2771, 2008.

Three-dimensional modeling and computational analysis of the human cornea considering distributed collagen fibril orientations. ASME Journal of Biomechanical Engineering, 130:061006, 2008.

Mechanical stresses in abdominal aortic aneurysms: influence of diameter, asymmetry and material anisotropy. ASME Journal of Biomechanical Engineering, 130:021023, 2008.

Dissection properties of the human aortic media: an experimental study. ASME Journal of Biomechanical Engineering, 130:021007, 2008.

In vivo characterization of the mechanics of human uterine cervices. Annals of the New York Academy of Sciences, 1101:186-202, 2007

A constitutive model for fibrous tissues considering collagen fiber crimp. International Journal of Non-Linear Mechanics, 42:391-402, 2007.

Finite element modeling of balloon angioplasty by considering overstretch of remnant non-diseased tissues in lesions, Computational Mechanics, 40:47-60, 2007.

Modeling plaque fissuring and dissection during balloon angioplasty intervention. Annals of Biomedical Engineering, 35:711-723, 2007.

Stress-modulated collagen fiber remodeling in a human carotid bifurcation. Journal of Theoretical Biology, 248:460–470, 2007.

Biomechanical characterization of the stented artery. Computational solid mechanical aspects. In: N. Chakfé, B. Durand and J.-G. Kretz (eds.), "ESVB 2007 – New Technologies in Vascular Biomaterials. Fundamentals About Stents II", Chapter 2, Europrot, Strasbourg, France (2007), 11-23.

Computational stress-deformation analysis of arterial walls including high-pressure response. International Journal of Cardiology, 116:78-85, 2007.

Layer-specific 3D residual deformations of human aortas with non-atherosclerotic intimal thickening. Annals of Biomedical Engineering, 35:530-545, 2007.

Characterizing the mechanical response of soft human tissue for medical applications. In: E. Oñate, D.R.J. Owen and B. Suárez (eds.), "Computational Plasticity IX. Fundamentals and Applications", CIMNE, Barcelona, Spain (2007), 244-247.

Mechanical stresses in abdominal aortic aneurysm. Material anisotropy a parametric study. In: E. Oñate, D.R.J. Owen and B. Suárez (eds.), "Computational Plasticity IX. Fundamentals and Applications", CIMNE, Barcelona, Spain (2007), 248-252.

Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. IEEE/ASME Journal of Microelectromechanical Systems, 16:1429-1440, 2007.

3-D reconstruction of tissue components for atherosclerotic human arteries using ex vivo high-resolution MRI. IEEE Transactions on Medical Imaging, 25:345-357, 2006.

A polyconvex framework for soft biological tissues. Adjustment to experimental data. International Journal of Solids and Structures, 43:6052-6070, 2006.

Brain tissue deforms similarly to filled elastomers and follows consolidation theory. Journal of the Mechanics and Physics of Solids, 54:2592-2620, 2006.

3D crack propagation in unreinfoced concrete. A two-step algorithm for tracking 3D crack paths. Computer Methods in Applied Mechanics and Engineering, 195:5198–5219, 2006.

Modeling the propagation of arterial dissection. European Journal of Mechanics A-Solids, 25:617-633, 2006.

Hyperelastic modelling of arterial layers with distributed collagen fibre orientations. Journal of the Royal Society Interface, 3:15-35, 2006.

Role of facet curvature for accurate vertebral facet load analysis. European Spine Journal, 15:849-856, 2006.

Determination of material models for arterial walls from uniaxial extension tests and histological structure. Journal of Theoretical Biology, 238:290-302, 2006

Patient-specific biomechanical analysis of plaque rupture during balloon angioplasty using MRI and mechanical testing. In: J. Burša and V. Fuis (eds.), "Proceedings of the Conference on Human Biomechanics 2006", Brno University of Technology, Brno (2006), 22-31.

Towards a computational methodology for optimizing angioplasty treatments with stenting. In: G.A. Holzapfel and R.W. Ogden (eds.), "Mechanics of Biological Tissue", Springer-Verlag Heidelberg (2006), 225-240.

Mechanical properties of the human uterine cervix: An in vivo study. Medical Image Analysis, 10:125-36, 2006.

In vivo experiments to characterize the mechanical behavior of the human uterine cervix. In: G.A. Holzapfel and R.W. Ogden (eds.), "Mechanics of Biological Tissue", Springer-Verlag Heidelberg, (2006), 398-408.

Bidirectional tensile testing cell for in situ small angle X-ray scattering investigations of soft tissue. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, B 246:262–268, 2006.

An automatic non-rigid registration for stained histological sections. IEEE Transactions on Image Processing, 13:475-486, 2005.

Computer vision analysis of collagen fiber bundles in the adventitia of human blood vessels. In: J.S. Suri, C. Yuan, D.L. Wilson and S. Laxminarayan (eds.), "Plaque Imaging: Pixel to Molecular Level. Studies in Health Technology and Informatics", Chapter 4, IOS Press (2005), 113:97-129.

Modeling 3D crack propagation in unreinforced concrete using PUFEM. Computer Methods in Applied Mechanics and Engineering, 194:2859-2896, 2005.

Physical and numerical modeling of dissection propagation in arteries caused by balloon angioplasty. In: M.H. Hamza (ed.), "Proceedings of the 3rd IASTED International Conference on Biomechanics", ACTA Press, Anaheim (2005), 229-233.

How to incorporate collagen fiber orientations in an arterial bifurcation? In: M.H. Hamza (ed.), "Proceedings of the 3rd IASTED International Conference on Biomechanics", ACTA Press, Anaheim (2005), 101-104.

Determination of layer-specific mechanical properties of human coronary arteries with non-atherosclerotic intimal thickening, and related constitutive modeling. American J. Physiology - Heart Circulation Physiology, 289:H2048-2058, 2005.

Changes in the mechanical environment of stenotic arteries during interaction with stents: Computational assessment of parametric stent designs. ASME Journal of Biomechanical Engineering, 127:166-180, 2005.

Single-lamellar mechanics of the human lumbar anulus fibrosus. Biomechanics and Modeling in Mechanobiology, 3:125-140, 2005.

Comparison of a structural model with a Fung-type model using a carotid artery: Issues of material stability. In: W. Ehlers and B. Markert (eds.), "Proceedings of the 1st GAMM Seminar on Continuum Biomechanics", Report No.: II-14, Institute of Applied Mechanics (CE), University of Stuttgart, 2005, 79-89.

Similarities between soft biological tissues and rubberlike materials. In: P.-E. Austrell and L. Keri (eds.), "Constitutive Models for Rubber IV", A.A. Balkema Publishers: Leiden (2005), 607-617.

On the modelling of amplitude and frequency-dependent mechanical properties in rubberlike solids. In: P.-E. Austrell and L. Keri (eds.), "Constitutive Models for Rubber IV", A.A. Balkema Publishers, Leiden (2005), 285-298.

In situ tensile testing of human aortas by time-resolved small angle X-ray scattering. Journal of Synchrotron Radiation, 12:727-733, 2005.

Non-rigid registration for stained histological sections of atherosclerotic arteries. In: B. Tilg (ed.), “Proceedings of the 2nd IASTED International Conference on Biomedical Engineering, CD-ROM”, Innsbruck, Austria (2004).

A new two-point deformation tensor and its relation to the classical kinematical framework and the stress concept. International Journal of Solids and Structures, 41:7459-7469, 2004.

Multi-Segment FEA of the human lumbar spine including the heterogeneity of the annulus fibrosus. Computational Mechanics, 34:147-163, 2004.

Automatic analysis of collagen fiber orientation in the outermost layer of human arteries. Pattern analysis and applications, 7:269-284, 2004.

Estimating the Stretching Characteristic of Fiber Bundles in Microscopic Images. In: J. Kittler and M. Petrou and M. Nixon (eds.), "Proceedings of the 17th International Conference on Pattern Recognition (ICPR'04)", Vol. 3, IEEE Computer Society Press, Cambridge, UK (2004), 546-549.

3D crack propagation in unreinforced concrete. Physical modeling and numerical analyses. In: G.A. Holzapfel, W. Moser and G. Reichard (eds.), "Advanced Numerical Analyses of Solids and Structures, and Beyond", Verlag der Technischen Universität Graz, 2004, ISBN 3-902465-01-8, 61-79.

On the mathematical modeling of three-dimensional delamination processes of laminated composites. In: D.Y. Gao (ed.), "Complementarity, Duality and Symmetry in Nonlinear Mechanics. Proceedings of the IUTAM Symposium", Kluwer Academic Publishers, Boston (2004), 85-99.

"Advanced Numerical Analyses of Solids and Structures, and Beyond", Verlag der Technischen Universität Graz, 2004, ISBN 3-902465-01-8.

Computational Biomechanics of Soft Biological Tissue. In: E. Stein, R. de Borst and T.J.R. Hughes (eds.), "Encyclopedia of Computational Mechanics", Volume 2 Solids and Structures, Chapter 18, John Wiley & Sons, Ltd: Chichester (2004), 605-635.

Anisotropic mechanical properties of tissue components in human atherosclerotic plaques. ASME Journal of Biomechanical Engineering, 126:657-665, 2004.

Comparison of a multi-layer structural model for arterial walls with a Fung-type model, and issues of material stability. ASME Journal of Biomechanical Engineering, 126:264-275, 2004.

Virtuelle Dilatation von atherosklerotischen Blutgefäßen: Hintergrund, Stand der Forschung und Ausblick. In: Forum Technik und Gesellschaft (ed.), "Zukunft durch Forschung – Forschung heißt Zukunft gestalten. Der Beitrag der Technischen Universität Graz", Schriften Band 3, Verlag der Technischen Universität Graz, Austria (2004), 108-116.

Assessment of plaque stability based on high-resolution magnetic resonance imaging of human atherosclerotic lesions and computational mechanical analysis. In: M. Cerrolaza, M. Doblaré, G. Martínez, and B. Calvo (eds.), "Computational Bioengineering: Current Trends and Applications", Imperial College Press: Singapore (2004), 101-115.

Subdivision schemes for smooth contact surfaces of arbitrary mesh topology in 3D. International Journal for Numerical Methods in Engineering, 60:1161-1195, 2004.

A phenomenological model for atherosclerotic plaque growth and rupture. Journal of Theoretical Biology, 227:437-443,2004.

"Structural analysis of collagen fibers based on microscopic images", in: C. Beleznai and T. Schlögl, eds., "Proceedings of the 27th Workshop of the Austrian Association for Pattern Recognition: Vision in a Dynamic World – Austrian Association for Pattern Recognition (AAPR)", Laxenburg, Austria (2003), 103-110.

"Robust segmentation of homogeneously oriented regions in microscopic biological soft tissue images", in: O. Drbohlav, ed., "Proceedings of the 8th Computer Vision Winter Workshop 2003 (Computer Vision – CVWW’03)", Valtice, Czech Republic (2003), 9-14.

Geometrically non-linear and consistently linearized embedded strong discontinuity models for 3D problems with an application to the dissection analysis of soft biological tissues. Computer Methods in Applied Mechanics and Engineering, 192:5059–5098, 2003.

Structural and numerical models for the (visco)elastic response of arterial walls with residual stresses. In: G.A. Holzapfel and R.W. Ogden (eds.), "Biomechanics of Soft Tissue in Cardiovascular Systems", CISM Courses and Lectures No. 441, International Centre for Mechanical Sciences, Springer: Wien, New York (2003), 109-184.

Passive biaxial mechanical response of aged human iliac arteries. ASME Journal of Biomechanical Engineering, 125:395-406, 2003.

Determination of constitutive equations for human arteries from clinical data. Journal of Biomechanics, 36:165-169, 2003.

Cⁿ continuous modeling of smooth contact surfaces using NURBS and applications to 2D problems. International Journal for Numerical Methods in Engineering, 57:2177-2203, 2003.

Segmentation of wall and plaque in in vitro vascular MR images. International Journal of Cardiovascular Imaging, 19:419-428, 2003.

A large strain continuum and numerical model for transformation induced plasticity (TRIP). In: H.A. Mang, F.G. Rammerstorfer, J. Eberhardsteiner (eds.), "Fifth World Congress on Computational Mechanics – WCCM V, CD-ROM", Vienna, Austria (2002).

Assessment of a Spinal Implant by Means of Accurate FE Modeling of Intact Human Intervertebral Discs. In: H.A. Mang, F.G. Rammerstorfer, J. Eberhardsteiner (eds.), "Fifth World Congress on Computational Mechanics – WCCM V, CD-ROM", Vienna, Austria (2002).

A three-dimensional finite element model for arterial clamping. ASME Journal of Biomechanical Engineering, 124:355-363, 2002.

A rate-independent elastoplastic constitutive model for (biological) fiber-reinforced composites at finite strains: Continuum basis, algorithmic formulation and finite element implementation. Computational Mechanics, 29:340-360, 2002.

Necking phenomena of a fiber-reinforced bar modeled by multisurface plasticity. In: Ch. Miehe (ed.), "IUTAM Symposium on Computational Mechanics of Solid Materials at Large Strains", Stuttgart, Germany, Kluwer Academic Publishers, Boston (2002), 211-220.

Failure analysis of arteries by means of discontinuous FE Modeling. In: H.A. Mang, F.G. Rammerstorfer, J. Eberhardsteiner (eds.), "Fifth World Congress on Computational Mechanics – WCCM V, CD-ROM", Vienna, Austria (2002).

Biomechanics of soft tissues with application to arterial walls. In: J.A.C. Martins and E.A.C. Borges Pires (eds.), "Mathematical and Computational Modeling of Biological Systems", Chapter 1, Centro Internacional de Matemática CIM: Coimbra, Portugal (2002), 1-37.

A structural model for the viscoelastic behavior of arterial walls: Continuum formulation and finite element analysis, European Journal of Mechanics A-Solids, 21:441-463,2002.

A layer-specific 3D model for the finite element simulation of balloon angioplasty using MR imaging and mechanical testing. Annals of Biomedical Engineering, 30:753-767, 2002.

Mechanics of the human femoral adventitia including high-pressure response. American J. Physiology - Heart Circulation Physiology, 282:H2427-40,2002.

Assessment of plaque stability by means of high-resolution MRI and finite element analyses of local stresses and strains. In: "Proceedings of 2002 International Symposium on Biomedical Imaging: Macro to Nano, CD-ROM", Los Alamitos, CA, IEEE (2002), TA-CS-4.1.

NURBS-based smooth surface contact for the numerical simulation of balloon angioplasty. In: H.A. Mang, F.G. Rammerstorfer, J. Eberhardsteiner (eds.), "Fifth World Congress on Computational Mechanics – WCCM V, CD-ROM", Vienna, Austria (2002).

An anisotropic model for annulus tissue and enhanced finite element analyses of intact lumbar disc bodies. Computer Methods in Biomechanics and Biomedical Engineering, 4:209-230, 2001.

Biomechanics of soft tissue. In: J. Lemaitre (ed.), "The Handbook of Materials Behavior Models", Volume III, Multiphysics Behaviors, Chapter 10, Composite Media, Biomaterials, Academic Press: Boston (2001), 1049-1063.

A viscoelastic model for fiber-reinforced composites at finite strains: Continuum basis, computational aspects and applications. Computer Methods in Applied Mechanics and Engineering, 190:4379-4430, 2001.

Mechanics of angioplasty: Wall, balloon and stent. In: J. Casey and G. Bao (eds.),
"Mechanics in Biology", AMD-Vol. 242, BED-Vol. 46, New York (2000), 141-156.

A new constitutive framework for arterial wall mechanics and a comparative study of material models. Journal of Elasticity, 61:1-48, 2000.